5 Best Natural Antidepressants


According to the World Health Organization, one in four people around the globe will experience some form of mental or neurological disorder at some point in their life. Currently, the gold standard to treat depression and anxiety is the infamous antidepressants, otherwise known as selective serotonin reuptake inhibitors (SSRIs) and monoamine oxidase inhibitors (MAOIs). In general, these substances work by changing the levels of certain chemicals in the brain, such as serotonin, dopamine, and norepinephrine. The problem with these substances is that they take weeks to be effective while they can be addictive, and ridden with side effects. But recently natural antidepressants have gained attention for their potential to uplift mood and alleviate depressive symptoms too. While treating depression and other mental illnesses always requires consultation with qualified healthcare professionals, and natural antidepressants are not as potent as the prescriptions ones, we believe it's important for everyone to have a full picture of all the available remedies out there.

Understanding Depression

Types of Depression

Depression takes many forms, ranging from major depressive disorder to seasonal affective disorder. Major depressive disorder is characterized by persistent feelings of hopelessness and a loss of interest in activities that were once enjoyed. On the other hand, seasonal affective disorder is a type of depression that occurs during specific times of the year, usually in the winter months, and can bring about an opportunity for self-reflection and growth.

Other types of major depression can include persistent depressive disorder, bipolar disorder, and postpartum depression, which can also be managed with proper treatment and support.

Understanding the different types of depression is crucial in finding the most effective treatment plan. By recognizing the specific form of depression one is experiencing, it becomes easier to tailor the treatment plan with targeted therapies and natural remedies. This personalized approach can significantly improve the chances of successfully managing depressive symptoms and leading a happier, healthier life.

Causes, Deficiencies, and Risk Factors

Depression can be caused by a combination of neurochemical inbalance, hormonal inbalance, poor gut health, genetic factors, environmental stressors, structural or functional brain abnormalities, and psychological effects. But causation and correlation is way less clear than we tend to think about it. Prescription antidepressant medications, like selective serotonin reuptake inhibitors (SSRIs) are aiming to fix the neurochemical inbalance, but 30% of patients show no improvement at all. And famous psychiatrist Dr. Gábor Máté argues that while the other 70% gets improvement from the elevated serotonin levels, but they are not actually addressing the root causes. The way he describes it: "If you go to a party and you're kind of socially shy and you have a drink, all of a sudden you become the life of the party. Does that prove that your social anxiety was caused by a lack of bourbon in your brain?"

While the deeper answers to causation and correlation won't be solved here, we can offere a comprehensive view of how supplements can play a supporting role in the treatment of depression. Some nutrients, such as B vitamins, magnesium, omega-3 fatty acids, vitamin D, and zinc, can help improve symptoms of depression and potentially enhance the effectiveness of medications. Ensuring adequate levels of these essential nutrients can help to reduce inflammation, support mood regulation, and improve overall mental health. By addressing deficiencies and incorporating nutrient-rich foods and supplements into one's daily routine, it is possible to make a positive impact on depression symptoms and overall well-being.

Natural Mood Boosters

Whether neurochemical inbalances are cause or causation when it comes to depression, it's clear that elevated serotonin can have a highly positive impact on mood disorders. So if you're looking to naturally boost your serotonin levels, there are several natural supplements that are believed to have mood-enhancing properties. But it's important to note that while these substances may have positive effects, their efficacy and safety may vary among individuals and it's always advisable to consult with a healthcare professional before starting any new supplement regimen, especially when it comes to serotonin boosting. But to have a wide picture of all natural remedies, in the following sections, we will explore each of the best natural mood boosters in detail, discussing their benefits and the scientific evidence supporting their use in managing depression.


5-HTP (5-hydroxytryptophan) is a naturally occurring compound that is derived from the amino acid tryptophan. It plays a crucial role in the production of serotonin, a neurotransmitter involved in mood regulation. By increasing the availability of tryptophan, 5-HTP can potentially enhance serotonin synthesis in the brain, leading to increased serotonin levels. The question arise why not take L-Tryptophan supplements instead and take out the middle man, but 5-HTP is generally recommended over l-tryptophan because it crosses the blood-brain barrier at a higher rate, and gets converted to serotonin more efficiently.

Several studies have explored the effects of 5-HTP on depression. Some research suggests that 5-HTP supplementation may improve mood, reduce symptoms of depression, and promote emotional well-being. It is believed that by raising serotonin levels, 5-HTP may enhance neurotransmission in brain circuits involved in mood regulation, leading to an improvement in mood disorder and in depressive symptoms. However, it is important to note that the results of these studies have been mixed, and more robust research is needed to establish the effectiveness of 5-HTP as a treatment for depression.

Mucuna Pruriens

Mucuna Pruriens, also known as velvet bean, is a natural source of L-dopa, which is a precursor to the neurotransmitter dopamine. Dopamine plays a crucial role in mood regulation, motivation, and reward. By increasing dopamine levels, Mucuna Pruriens can help improve mood and decrease stress and anxiety.

In addition to its mood-boosting effects, Mucuna Pruriens has also been traditionally used as an aphrodisiac and to treat nervous disorders moderate depression and arthritis. If you're looking for a natural herbal supplement, to enhance your mood and alleviate depression symptoms, Mucuna Pruriens may be an excellent option to consider.

SAM-e (S-adenosylmethionine)

SAM-e (S-adenosylmethionine) is a naturally occurring compound in the body that plays a vital role in various biochemical reactions, including the synthesis of neurotransmitters like serotonin and dopamine. It has been found that supplementing with SAM-e can help boost serotonin and dopamine activity in the brain and prevent the reuptake of norepinephrine, making it a popular choice for treating depression.

In addition to its antidepressant effects, SAM-e has been shown to have minimal side effects compared to pharmaceutical antidepressants. Jarrow Formulas SAM-e supplement is a highly praised option that offers an impressive 400 mg of SAM-e per tablet, making it an excellent choice for those considering using SAM-e to improve their mood and reduce depressive symptoms.


If gut health is the root problem, psychobiotics are a type of probiotics that can enhance gut and brain health, and mitigate inflammation. They have the potential to positively impact mental health by influencing the gut-brain axis, which is the communication pathway between the gut and the brain. With nine probiotic strains known to impact anxiety, psychobiotics can play a significant role in improving mood and reducing depressive symptoms.

Optimal Biotics is a powerful supplement that combines five of the best probiotics for promoting a positive mood, including Bifidobacterium longum, Lactobacillus acidophilus, Lactobacillus rhamnosus, Bifidobacterium bifidum, and Lactobacillus casei. By incorporating a psychobiotic supplement like Optimal Biotics into your daily routine, you can support your gut health and potentially experience an improvement in your mental well-being.


Magnesium is an essential mineral that plays a critical role in various physiological processes, including the regulation of neurotransmitters, which are crucial for mood regulation. Research suggests that supplementing with magnesium may help reduce depressive symptoms, especially among those with depression. Taking 248 mg of magnesium per day for 6 weeks has been found to significantly improve depressive symptoms compared with a placebo.

Alternative Therapies and Lifestyle Changes

While natural supplements can provide significant health benefits for individuals struggling with depression, it is essential to consider alternative therapies and lifestyle changes that can further improve mental health.

In the following sections, we will explore various therapies and lifestyle habits that can complement the use of natural antidepressants and help manage depression more effectively.


Therapy is an essential component of depression treatment, with various types of therapy demonstrating effectiveness in managing depressive symptoms. Cognitive behavioral therapy, interpersonal therapy, and psychodynamic therapy are all proven treatments for depression and can provide invaluable support and coping strategies for individuals struggling with this mental health condition.

Online therapy is a convenient and beneficial option for those who have difficulty attending in-person appointments or have busy schedules. Additionally, cost-effective therapy options like training clinics or providers offering a sliding scale payment can help make therapy more accessible to those in need.

By incorporating therapy into your depression treatment plan, you can better understand and manage your mental health condition while benefiting from professional guidance and support.

Mindfulness and Meditation

Mindfulness and meditation are powerful techniques that bring awareness to the present moment and one's thoughts, feelings, and sensations. Practicing mindfulness and meditation has been found to lower cortisol levels, a hormone associated with an improved mood when regulated. By incorporating mindfulness and meditation practices into your daily routine, you can better manage stress and negative emotions, leading to a more balanced and positive mental state.

There are various resources available to help you get started with mindfulness and meditation. Calm, Headspace, and Insight Timer are fantastic meditation apps that offer guided meditations and mindfulness exercises tailored to your needs and preferences. Additionally, you can find plenty of free guided videos for yoga and meditation on YouTube.

By doing more research and dedicating time each day to mindfulness and meditation practices, you can significantly improve your mental health and overall well-being.

Nutrition and Dietary supplements

A nutritious diet and a healthy lifestyle play a crucial role in managing depression and improving mental health. Eating a balanced diet that includes a variety of fruits, vegetables, whole grains, fish, low-fat dairy, and antioxidants, and limits processed and sugary foods can have a positive impact on depression symptoms and overall well-being.

Maintaining steady blood sugar levels is also essential for optimal mental health. Incorporating whole grains, fruits, and vegetables into your diet instead of white flour, sugar, rice, and potatoes can help keep blood sugar levels stable.

By being mindful of your diet and making healthier food choices, you can better manage depression symptoms and experience a greater sense of balance and well-being.

Precautions and Consultation

When considering natural antidepressants, it's essential to be aware of potential interactions, side effects, and the importance of consulting with healthcare professionals.

In the following sections, we will discuss these precautions and emphasize the value of creating a customized treatment plan under the guidance of a healthcare professional.

Potential Interactions and Side Effects

It's important to consider potential interactions and side effects when using natural supplements for depression. Some herbal supplements also can interact with medications or other supplements, resulting in enhanced or diminished effects. For example, combining St. John's with St. John's is a good idea. Wort with other antidepressants such as Prozac may result in improved serotonin levels. However, this can also lead to serotonin syndrome, a potentially life-threatening condition.

By consulting with a healthcare professional before taking any natural or antidepressant medication, you can create an effective and safe treatment plan tailored to your individual needs. This will help ensure that you're using natural remedies safely and effectively while minimizing the risk of adverse effects or interactions with other medications.

Beware of St. John's Wort

St. John's. Wort is a natural antidepressant that's sometimes gets cautiously recommended for it's serotonin boosting quality, but it should be used with caution due to its potentially lethal interactions with other medicines, birth control pills, antidepressants, or blood-thinning drugs.

Customized Treatment Plans

Creating a customized treatment plan under the guidance of a healthcare professional is essential when considering natural antidepressants and therapies for depression management. If you're currently on SSRIs, MAOIs or any other psychiatric medicines, stay clear of nootropics, and even after you stop taking them consult with your doctor on when you can introduce any new supplement to your diet.


In conclusion, natural antidepressants, alternative therapies, and lifestyle changes can play a significant role in managing depression and improving mental health. By exploring various natural mood boosters, engaging in mindfulness and meditation practices, maintaining a nutritious diet, and consulting with healthcare professionals to create a customized treatment plan, you can take control of your mental health and lead a happier, healthier life. We hope that this comprehensive guide to prescription antidepressants has provided you with valuable insights and inspiration to explore the world of natural antidepressants and make informed choices for your well-being.

Peter V

Not living up to my potential since 1990.As a functional dysfunctional who got max points on the ADHD diagnostic test, I’m dedicated to help people on their mental health journey and to provide them information on how to support their brains to unlock their full potential.

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